Project name: Biodegradable implants in porous iron obtained by additive manufacturing
Project code: GradImp
Project timeline: 2022 - 2024
Research group: Mechanical Design
Objective
Biodegradable devices have the potential to become successful candidates for temporary medical implant devices, as they are able to degrade in the human body upon tissue healing, reducing the costs of additional removal surgery. To accomplish the challenge of producing such complex structures, an advanced method of additive manufacturing (AM), such as sintered laser melting (SLM) will be used. This new line of research will evaluate the effect of the design of the iron scaffold, produced by additive manufacturing, in the resulting properties, to obtain the suitable characteristics for temporary bone implants. Prototypes will be developed and submitted to cytocompatibility and microbiology assays. The combination of biodegradable iron and additive manufacturing (AM) leads to a revolutionary change of metal implants in many aspects including materials, design, manufacturing, and clinical applications.
Project team
Publications
Pedro Nogueira, Beatriz Rodrigues, P Lopes, L Oliveira, JL Alves, João Pedro Grosa Magrinho, M.Beatriz Silva, M. Fátima Vaz, Bending properties of additively manufactured lattice structures for bone implants, MDA2024, 5th International Conference on Materials Design and Applications, FEUP, Porto, Jul, 2024
Pedro Nogueira, Pedro Lopes, Luís Oliveira, Jorge Alves, João Magrinho, Augusto Moita de Deus, M. Fátima Vaz, M.Beatriz Silva, Evaluation of Lattice Structures for Medical Implants: A Study on the Mechanical Properties of Various Unit Cell Types, Metals, 14, 780, 2024
Pedro Nogueira, João Magrinho, Luis Reis, Augusto Moita de Deus, M.Beatriz Silva, Pedro Lopes, Luís Oliveira, António Castela, Ricardo Cláudio, Jorge Alves, M. Fátima Vaz, Maria Carmezim, Mechanical and Corrosion Behaviour in Simulated Body Fluid of As-Fabricated 3D Porous L-PBF 316L Stainless Steel Structures for Biomedical Implants, Journal of Functional Biomaterials, 15, 313, 2024
Pedro Nogueira, M.Beatriz Silva, Augusto Moita de Deus, M. Fátima Vaz, João Magrinho, Compression properties of cellular iron lattice structures used to mimic bone characteristics, Proceedings of the Institution of Mechanical Engineers, Part L: Journal of Materials: Design and Applications, 238, 2217-2232, 2024
Pedro Nogueira, M.Beatriz Silva, Augusto Moita de Deus, Ricardo L. D. Cláudio, Maria João Carmezim, Catarina Santos, João Pedro Grosa Magrinho, Luis Reis, Jorge Lino, Luís Oliveira, Pedro Lopes, Ana Serro, Diana Silva, M. Fátima Vaz, Evaluation of the roughness of lattice structures of AISI 316 stainless steel produced by laser powder bed fusion, 2024
Pedro Lopes, Fahad Zafar, Catarina Costa, João Castro, João Matos, Pedro Nogueira, João Magrinho, Augusto Moita de Deus, M. Fátima Vaz, M.Beatriz Silva, Luís Oliveira, Jorge Alves, A comprehensive study of LPBF parameter influence in 316L stainless steel mechanical properties, macrostructure, and printability, Proceedings of the Institution of Mechanical Engineers, Part L: Journal of Materials: Design and Applications, 2024
Mariana Salama, Porous Iron Biodegradable Structures, IST, UL, Jul, 2023
Pedro Nogueira, João Magrinho, M.Beatriz Silva, Augusto Moita de Deus, M. Fátima Vaz, Graded Lattice Structures for Biodegradable Temporary Implants: Computational Evaluation with Two Unit Cell Types, Towards a Smart, Resilient and Sustainable Industry. ISIEA 2023, Jun, 2023
Mariana Salama, Frederico Alves, Luis Reis, Augusto Moita de Deus, M.Beatriz Silva, Catarina Santos, M.J. Carmezim, M. Fátima Vaz, Mechanical and corrosion performance of biodegradable iron porous structures, Proceedings of the Institution of Mechanical Engineers, Part L: Journal of Materials: Design and Applications, 238, 204-220, 2024
Pedro Nogueira, João Magrinho, M.Beatriz Silva, Augusto Moita de Deus, M. Fátima Vaz, Towards a Smart, Resilient and Sustainable Industry. ISIEA 2023. Lecture Notes in Networks and Systems, Graded Lattice Structures for Biodegradable Temporary Implants: Computational Evaluation with Two Unit Cell Type, Jul, 2023, Springer
Mariana Salama, Frederico Alves, Luis Reis, Augusto Moita de Deus, M.Beatriz Silva, Catarina Santos, M.J. Carmezim, M. Fátima Vaz, Finite element simulations of mechanical behaviour and degradation of iron lattices, Proceedings of the Institution of Mechanical Engineers, Part L: Journal of Materials: Design and Applications, 237, 1379-1393, 2023
Pedro Nogueira, Kerman Castresana, João Magrinho, M.Beatriz Silva, Augusto Moita de Deus, M. Fátima Vaz, Computational evaluation of the compressive properties of different lattice geometries to be used as temporary implants, Procedia Computer Science, Nov, 2022
Mariana Salama, Frederico Alves, Luis Reis, Augusto Moita de Deus, M.Beatriz Silva, Catarina Santos, M.J. Carmezim, M. Fátima Vaz, Finite element simulations of mechanical behaviour and degradation of iron lattices, MDA 2022, 4th International Conference on Materials Design and Applications, 7-8 July , Jul, 2022
Guilherme Opinião, Manuel Sardinha, Nuno A. Ribeiro, M. Fátima Vaz, Luis Reis, Development of a fused filament fabricated bioabsorbable interference screw for anterior cruciate ligament regeneration, Procedia Structural Integrity, 42, 2022
Mariana Salama, M. Fátima Vaz, Rogério Colaço, Catarina Santos, M.J. Carmezim, Biodegradable Iron and Porous Iron: mechanical properties, degradation behaviour, manufacturing routes and biomedical applications, Journal of Functional Biomaterials , 13, 1-31, 2022
J.C.C. Paiva, Luis Oliveira, M. Fátima Vaz, Sofia Costa-de-Oliveira, Bioengineering Biodegradable Bone Implants as a New Hope to Reduce Device-Associated Infections?A Systematic Review, Bioengineering, 9, 409, 1-35, 2022
Pedro Nogueira, Desenvolvimento de implantes biodegradáveis de ferro poroso obtidos por fabrico aditivo (Development of biodegradable implants in porous iron obtained by additive manufacturing), IST, UL, Work in progress